Nanodropper Data.
BENCHTOP TESTING
Nanodropper-Mediated Drop Volume Reduction of Solutions, Suspensions & Emulsions
Nanodropper decreases the volume of eyedrops of nine different ophthalmic medications. (A) Visual comparison of drops produced from the original bottle (left) and with Nanodropper attached (right). (B) Mean volume of current eyedrops and Nanodropper-mediated microdrops collected for nine different drugs. n = 2 bottles. Two-way ANOVA with Sidak’s post-hoc tests; interaction of Drug x Dispenser, F(8,18)=5.0, P=0.0022; main effect of drug, F(8, 18)=34.8, P<0.0001; main effect of dispenser, F(1,18)=1138, P<0.0001. (C) Mean volume of current eyedrops and Nanodropper-mediated microdrops from all nine medications combined. n = 18 bottles. Unpaired t-test; t(34)=10.72, P<0.0001. (D) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the six ocular hypotensive prescription medications used to treat glaucoma: Lumigan, Timolol, Alphagan P, Combigan, Cosopt, and Azopt. n = 12 bottles. Unpaired t-test; t(22)=7.7, P<0.0001. (E) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the five tested medications that are formulated as solutions: Lumigan, Timolol, Alphagan P, Combigan, and Cosopt. n = 10 bottles. Unpaired t-test; t(18)=6.8, P<0.0001. (F) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the two tested medications that are formulated as suspensions: Azopt and Pred Forte. n = 4 bottles. Unpaired t-test; t(6)=8.2, P=0.0002. (G) Mean volume of current eyedrops and Nanodropper-mediated microdrops of the two tested medications that are formulated as emulsions: Systane and Systane Complete. n = 4 bottles. Unpaired t-test; t(6)=6.9, P=0.0005. Error bars, SEM, *P<0.0001, **P<0.01.
References: (A) Nanodropper, Inc. (B)-(G) St. Peter et al., 2022, unpublished.
Benchtop data collected in collaboration with University of Colorado Anschutz Medical Campus, Department of Ophthalmology.